Gene-specific Break Apart Probe-PEG10

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Catalog:	GBAFP-PEG10-15717
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (PEG10). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	PEG10 Gene-specific Break Apart Probe is designed to detect potential PEG10 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Paternally Expressed 10
Gene Summary [Provided by RefSeq]	This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
Gene Symbol	PEG10
Location	7q21.3
Chromosome	Chromosome7
Coordinates	This gene maps to 94285636-94299006 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-PEG10-15717-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-PEG10-15717-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-PEG10-15717-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-PEG10-15717-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-PEG10-15717-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-PEG10-15717-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-PEG10-15717-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-PEG10-15717-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-PEG10-15717-REGR	599nm;515nm	580nm;491nm

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