Gene-specific Break Apart Probe-LRTOMT

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Catalog:	GBAFP-LRTOMT-13787
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (LRTOMT). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	LRTOMT Gene-specific Break Apart Probe is designed to detect potential LRTOMT rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Leucine Rich Transmembrane And O-methyltransferase Domain Containing
Gene Summary [Provided by RefSeq]	This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017]
Gene Symbol	LRTOMT
Location	11q13.4
Chromosome	Chromosome11
Coordinates	This gene maps to 71791376-71821828 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-LRTOMT-13787-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-LRTOMT-13787-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-LRTOMT-13787-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-LRTOMT-13787-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-LRTOMT-13787-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-LRTOMT-13787-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-LRTOMT-13787-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-LRTOMT-13787-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-LRTOMT-13787-REGR	599nm;515nm	580nm;491nm

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