Gene-specific Break Apart Probe-LAMC1

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Catalog:	GBAFP-LAMC1-13466
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (LAMC1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	LAMC1 Gene-specific Break Apart Probe is designed to detect potential LAMC1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Laminin Subunit Gamma 1
Gene Summary [Provided by RefSeq]	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
Gene Symbol	LAMC1
Location	1q25.3
Chromosome	Chromosome1
Coordinates	This gene maps to 182992594-183114727 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-LAMC1-13466-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-LAMC1-13466-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-LAMC1-13466-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-LAMC1-13466-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-LAMC1-13466-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-LAMC1-13466-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-LAMC1-13466-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-LAMC1-13466-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-LAMC1-13466-REGR	599nm;515nm	580nm;491nm

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