Gene-specific Break Apart Probe-LAMB2

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Catalog:	GBAFP-LAMB2-03989
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (LAMB2). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	LAMB2 Gene-specific Break Apart Probe is designed to detect potential LAMB2 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Laminin Subunit Beta 2
Gene Summary [Provided by RefSeq]	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]
Gene Symbol	LAMB2
Location	3p21.31
Chromosome	Chromosome3
Coordinates	This gene maps to 49158546-49170599 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-LAMB2-03989-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-LAMB2-03989-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-LAMB2-03989-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-LAMB2-03989-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-LAMB2-03989-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-LAMB2-03989-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-LAMB2-03989-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-LAMB2-03989-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-LAMB2-03989-REGR	599nm;515nm	580nm;491nm

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