Gene-specific Break Apart Probe-KLRK1

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Catalog:	GBAFP-KLRK1-03959
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (KLRK1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	KLRK1 Gene-specific Break Apart Probe is designed to detect potential KLRK1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Killer Cell Lectin Like Receptor K1
Gene Summary [Provided by RefSeq]	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
Gene Symbol	KLRK1
Location	12p13.2
Chromosome	Chromosome12
Coordinates	This gene maps to 10524951-10542653 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-KLRK1-03959-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-KLRK1-03959-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-KLRK1-03959-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-KLRK1-03959-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-KLRK1-03959-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-KLRK1-03959-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-KLRK1-03959-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-KLRK1-03959-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-KLRK1-03959-REGR	599nm;515nm	580nm;491nm

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