Gene-specific Break Apart Probe-KIR2DL4

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Catalog:	GBAFP-KIR2DL4-13397
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (KIR2DL4). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	KIR2DL4 Gene-specific Break Apart Probe is designed to detect potential KIR2DL4 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4
Gene Summary [Provided by RefSeq]	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
Gene Symbol	KIR2DL4
Location	19q13.42
Chromosome	Chromosome19_gl000209_random
Coordinates	This gene maps to 57208-68123 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-KIR2DL4-13397-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-KIR2DL4-13397-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-KIR2DL4-13397-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-KIR2DL4-13397-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-KIR2DL4-13397-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-KIR2DL4-13397-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-KIR2DL4-13397-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-KIR2DL4-13397-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-KIR2DL4-13397-REGR	599nm;515nm	580nm;491nm

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