Gene-specific Break Apart Probe-HTT

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Catalog:	GBAFP-HTT-12974
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (HTT). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	HTT Gene-specific Break Apart Probe is designed to detect potential HTT rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Huntingtin
Gene Summary [Provided by RefSeq]	Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
Gene Symbol	HTT
Location	4p16.3
Chromosome	Chromosome4
Coordinates	This gene maps to 3076407-3245687 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-HTT-12974-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-HTT-12974-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-HTT-12974-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-HTT-12974-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-HTT-12974-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-HTT-12974-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-HTT-12974-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-HTT-12974-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-HTT-12974-REGR	599nm;515nm	580nm;491nm

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