Gene-specific Break Apart Probe-HSPG2

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Catalog:	GBAFP-HSPG2-03434
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (HSPG2). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	HSPG2 Gene-specific Break Apart Probe is designed to detect potential HSPG2 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Heparan Sulfate Proteoglycan 2
Gene Summary [Provided by RefSeq]	This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Symbol	HSPG2
Location	1p36.12
Chromosome	Chromosome1
Coordinates	This gene maps to 22148736-22263750 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-HSPG2-03434-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-HSPG2-03434-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-HSPG2-03434-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-HSPG2-03434-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-HSPG2-03434-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-HSPG2-03434-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-HSPG2-03434-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-HSPG2-03434-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-HSPG2-03434-REGR	599nm;515nm	580nm;491nm

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