Gene-specific Break Apart Probe-HAS1

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Catalog:	GBAFP-HAS1-03086
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (HAS1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	HAS1 Gene-specific Break Apart Probe is designed to detect potential HAS1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Hyaluronan Synthase 1
Gene Summary [Provided by RefSeq]	Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Symbol	HAS1
Location	19q13.41
Chromosome	Chromosome19
Coordinates	This gene maps to 52216364-52227221 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-HAS1-03086-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-HAS1-03086-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-HAS1-03086-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-HAS1-03086-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-HAS1-03086-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-HAS1-03086-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-HAS1-03086-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-HAS1-03086-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-HAS1-03086-REGR	599nm;515nm	580nm;491nm

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