Gene-specific Break Apart Probe-GPX4

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Catalog:	GBAFP-GPX4-12601
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (GPX4). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	GPX4 Gene-specific Break Apart Probe is designed to detect potential GPX4 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Glutathione Peroxidase 4
Gene Summary [Provided by RefSeq]	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Gene Symbol	GPX4
Location	19p13.3
Chromosome	Chromosome19
Coordinates	This gene maps to 1103935-1106787 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-GPX4-12601-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-GPX4-12601-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-GPX4-12601-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-GPX4-12601-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-GPX4-12601-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-GPX4-12601-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-GPX4-12601-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-GPX4-12601-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-GPX4-12601-REGR	599nm;515nm	580nm;491nm

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