Gene-specific Break Apart Probe-GPX1

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Catalog:	GBAFP-GPX1-03013
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (GPX1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	GPX1 Gene-specific Break Apart Probe is designed to detect potential GPX1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Glutathione Peroxidase 1
Gene Summary [Provided by RefSeq]	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]
Gene Symbol	GPX1
Location	3p21.31
Chromosome	Chromosome3
Coordinates	This gene maps to 49394608-49395791 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-GPX1-03013-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-GPX1-03013-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-GPX1-03013-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-GPX1-03013-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-GPX1-03013-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-GPX1-03013-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-GPX1-03013-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-GPX1-03013-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-GPX1-03013-REGR	599nm;515nm	580nm;491nm

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