Gene-specific Break Apart Probe-GP1BB

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Catalog:	GBAFP-GP1BB-12498
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (GP1BB). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	GP1BB Gene-specific Break Apart Probe is designed to detect potential GP1BB rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Glycoprotein Ib Platelet Beta Subunit
Gene Summary [Provided by RefSeq]	Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
Gene Symbol	GP1BB
Location	22q11.21
Chromosome	Chromosome22
Coordinates	This gene maps to 19711065-19712297 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-GP1BB-12498-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-GP1BB-12498-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-GP1BB-12498-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-GP1BB-12498-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-GP1BB-12498-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-GP1BB-12498-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-GP1BB-12498-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-GP1BB-12498-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-GP1BB-12498-REGR	599nm;515nm	580nm;491nm

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