Gene-specific Break Apart Probe-GNAS

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Catalog:	GBAFP-GNAS-12546
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (GNAS). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	GNAS Gene-specific Break Apart Probe is designed to detect potential GNAS rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	GNAS Complex Locus
Gene Summary [Provided by RefSeq]	This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Symbol	GNAS
Location	20q13.32
Chromosome	Chromosome20
Coordinates	This gene maps to 57414794-57486250 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-GNAS-12546-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-GNAS-12546-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-GNAS-12546-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-GNAS-12546-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-GNAS-12546-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-GNAS-12546-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-GNAS-12546-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-GNAS-12546-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-GNAS-12546-REGR	599nm;515nm	580nm;491nm

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