Gene-specific Break Apart Probe-FURIN

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Catalog:	GBAFP-FURIN-12341
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (FURIN). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	FURIN Gene-specific Break Apart Probe is designed to detect potential FURIN rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Furin, Paired Basic Amino Acid Cleaving Enzyme
Gene Summary [Provided by RefSeq]	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Symbol	FURIN
Location	15q26.1
Chromosome	Chromosome15
Coordinates	This gene maps to 91411884-91426687 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-FURIN-12341-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-FURIN-12341-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-FURIN-12341-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-FURIN-12341-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-FURIN-12341-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-FURIN-12341-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-FURIN-12341-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-FURIN-12341-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-FURIN-12341-REGR	599nm;515nm	580nm;491nm

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