Gene-specific Break Apart Probe-FMO3

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Catalog:	GBAFP-FMO3-12253
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (FMO3). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	FMO3 Gene-specific Break Apart Probe is designed to detect potential FMO3 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Flavin Containing Monooxygenase 3
Gene Summary [Provided by RefSeq]	Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Gene Symbol	FMO3
Location	1q24.3
Chromosome	Chromosome1
Coordinates	This gene maps to 171060017-171086959 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-FMO3-12253-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-FMO3-12253-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-FMO3-12253-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-FMO3-12253-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-FMO3-12253-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-FMO3-12253-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-FMO3-12253-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-FMO3-12253-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-FMO3-12253-REGR	599nm;515nm	580nm;491nm

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