Gene-specific Break Apart Probe-FGFR1

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Catalog:	GBAFP-FGFR1-19382
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (FGFR1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	FGFR1 Gene-specific Break Apart Probe is designed to detect potential FGFR1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Fibroblast Growth Factor Receptor 1
Gene Summary [Provided by RefSeq]	The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Symbol	FGFR1
Location	8p11.23
Chromosome	Chromosome8
Coordinates	This gene maps to 38268655-38326352 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-FGFR1-19382-ORGR	573nm;515nm	548nm;491nm
2	RE; GR	GBAFP-FGFR1-19382-REGR	599nm;515nm	580nm;491nm
3	GR; OR	GBAFP-FGFR1-19382-GROR	515nm;573nm	491nm;548nm
4	GR; GO	GBAFP-FGFR1-19382-GRGO	515nm;551nm	491nm;525nm
5	GO; GR	GBAFP-FGFR1-19382-GOGR	551nm;515nm	525nm;491nm
6	GR; RE	GBAFP-FGFR1-19382-GRRE	515nm;599nm	491nm;580nm

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