Gene-specific Break Apart Probe-DIO3

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Catalog:	GBAFP-DIO3-11569
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (DIO3). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	DIO3 Gene-specific Break Apart Probe is designed to detect potential DIO3 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Iodothyronine Deiodinase 3
Gene Summary [Provided by RefSeq]	The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]
Gene Symbol	DIO3
Location	14q32.31
Chromosome	Chromosome14
Coordinates	This gene maps to 102027687-102029789 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-DIO3-11569-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-DIO3-11569-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-DIO3-11569-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-DIO3-11569-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-DIO3-11569-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-DIO3-11569-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-DIO3-11569-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-DIO3-11569-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-DIO3-11569-REGR	599nm;515nm	580nm;491nm

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