Gene-specific Break Apart Probe-DIO2

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Catalog:	GBAFP-DIO2-01999
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (DIO2). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	DIO2 Gene-specific Break Apart Probe is designed to detect potential DIO2 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Iodothyronine Deiodinase 2
Gene Summary [Provided by RefSeq]	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2016]
Gene Symbol	DIO2
Location	14q31.1
Chromosome	Chromosome14
Coordinates	This gene maps to 80663867-80697397 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-DIO2-01999-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-DIO2-01999-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-DIO2-01999-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-DIO2-01999-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-DIO2-01999-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-DIO2-01999-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-DIO2-01999-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-DIO2-01999-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-DIO2-01999-REGR	599nm;515nm	580nm;491nm

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