Gene-specific Break Apart Probe-CHRNA7

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Catalog:	GBAFP-CHRNA7-11038
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (CHRNA7). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	CHRNA7 Gene-specific Break Apart Probe is designed to detect potential CHRNA7 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Cholinergic Receptor Nicotinic Alpha 7 Subunit
Gene Summary [Provided by RefSeq]	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Symbol	CHRNA7
Location	15q13.3
Chromosome	Chromosome15
Coordinates	This gene maps to 32322690-32462384 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-CHRNA7-11038-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-CHRNA7-11038-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-CHRNA7-11038-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-CHRNA7-11038-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-CHRNA7-11038-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-CHRNA7-11038-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-CHRNA7-11038-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-CHRNA7-11038-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-CHRNA7-11038-REGR	599nm;515nm	580nm;491nm

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