Gene-specific Break Apart Probe-CALR

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Catalog:	GBAFP-CALR-10544
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (CALR). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	CALR Gene-specific Break Apart Probe is designed to detect potential CALR rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Calreticulin
Gene Summary [Provided by RefSeq]	Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
Gene Symbol	CALR
Location	19p13.13
Chromosome	Chromosome19
Coordinates	This gene maps to 13049413-13055304 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-CALR-10544-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-CALR-10544-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-CALR-10544-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-CALR-10544-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-CALR-10544-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-CALR-10544-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-CALR-10544-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-CALR-10544-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-CALR-10544-REGR	599nm;515nm	580nm;491nm

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