Gene-specific Break Apart Probe-CACNA1A

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Catalog:	GBAFP-CACNA1A-01033
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (CACNA1A). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	CACNA1A Gene-specific Break Apart Probe is designed to detect potential CACNA1A rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Calcium Voltage-gated Channel Subunit Alpha1 A
Gene Summary [Provided by RefSeq]	Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
Gene Symbol	CACNA1A
Location	19p13.13
Chromosome	Chromosome19
Coordinates	This gene maps to 13317255-13617274 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-CACNA1A-01033-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-CACNA1A-01033-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-CACNA1A-01033-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-CACNA1A-01033-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-CACNA1A-01033-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-CACNA1A-01033-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-CACNA1A-01033-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-CACNA1A-01033-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-CACNA1A-01033-REGR	599nm;515nm	580nm;491nm

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