Gene-specific Break Apart Probe-AZIN1

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Catalog:	GBAFP-AZIN1-00587
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (AZIN1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	AZIN1 Gene-specific Break Apart Probe is designed to detect potential AZIN1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Antizyme Inhibitor 1
Gene Summary [Provided by RefSeq]	The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Gene Symbol	AZIN1
Location	8q22.3
Chromosome	Chromosome8
Coordinates	This gene maps to 103838535-103876397 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-AZIN1-00587-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-AZIN1-00587-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-AZIN1-00587-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-AZIN1-00587-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-AZIN1-00587-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-AZIN1-00587-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-AZIN1-00587-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-AZIN1-00587-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-AZIN1-00587-REGR	599nm;515nm	580nm;491nm

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