Gene-specific Break Apart Probe-ATXN1

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Catalog:	GBAFP-ATXN1-00602
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (ATXN1). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	ATXN1 Gene-specific Break Apart Probe is designed to detect potential ATXN1 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Ataxin 1
Gene Summary [Provided by RefSeq]	The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). Alternative splicing results in multiple transcript variants, with one variant encoding multiple distinct proteins, ATXN1 and Alt-ATXN1, due to the use of overlapping alternate reading frames. [provided by RefSeq, Nov 2017]
Gene Symbol	ATXN1
Location	6p22.3
Chromosome	Chromosome6
Coordinates	This gene maps to 16299342-16761721 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	GR; OR	GBAFP-ATXN1-00602-GROR	515nm;573nm	491nm;548nm
2	AQ; OR	GBAFP-ATXN1-00602-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-ATXN1-00602-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-ATXN1-00602-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-ATXN1-00602-GRGO	515nm;551nm	491nm;525nm
6	GR; RE	GBAFP-ATXN1-00602-GRRE	515nm;599nm	491nm;580nm
7	OR; GR	GBAFP-ATXN1-00602-ORGR	573nm;515nm	548nm;491nm
8	RE; GO	GBAFP-ATXN1-00602-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-ATXN1-00602-REGR	599nm;515nm	580nm;491nm

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