Gene-specific Break Apart Probe-ADD3

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Catalog:	GBAFP-ADD3-09644
Classification:	Gene-specific Break Apart Probes
Description:	Our Gene-specific Break Apart Probes usually target the flanks of the target gene (ADD3). Due to this design method, our probe products can detect chromosomal rearrangements, such as translocations, by FISH.The product usually consists of a reagent combination composed of a probe with a selected dye color and a hybridization reagent.
Application:	ADD3 Gene-specific Break Apart Probe is designed to detect potential ADD3 rearrangements. This probe has been confirmed on the metaphase and interphase chromosomes by FISH. We provide a variety of dye color combinations for Break Apart Probes for customers to choose from. Probe products not only provide some classic color combinations, but also provide customized probe services.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	Within 10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name	Adducin 3
Gene Summary [Provided by RefSeq]	Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Gene Symbol	ADD3
Location	10q25.1-q25.2
Chromosome	Chromosome10
Coordinates	This gene maps to 111765725-111895323 in GRCh37 coordinates.
Species	Human

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	OR; GR	GBAFP-ADD3-09644-ORGR	573nm;515nm	548nm;491nm
2	AQ; OR	GBAFP-ADD3-09644-AQOR	467nm;573nm	418nm;548nm
3	GO; GR	GBAFP-ADD3-09644-GOGR	551nm;515nm	525nm;491nm
4	GO; RE	GBAFP-ADD3-09644-GORE	551nm;599nm	525nm;580nm
5	GR; GO	GBAFP-ADD3-09644-GRGO	515nm;551nm	491nm;525nm
6	GR; OR	GBAFP-ADD3-09644-GROR	515nm;573nm	491nm;548nm
7	GR; RE	GBAFP-ADD3-09644-GRRE	515nm;599nm	491nm;580nm
8	RE; GO	GBAFP-ADD3-09644-REGO	599nm;551nm	580nm;525nm
9	RE; GR	GBAFP-ADD3-09644-REGR	599nm;515nm	580nm;491nm

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