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XBP1-UTRN Gene Fusion FISH Probe

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Catalog: GFFP-XBP1/UTRN-13246
Classification: Gene Fusion FISH Probes
Description: The XBP1-UTRN Gene Fusion FISH Probecan detect the fusion of XBP1 and UTRN genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: XBP1-UTRN Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Utrophin
Gene Summary 1 This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 6
Locus 1 6q24.2
Coordinates 1 This gene maps to 144612872-145174170 in GRCh37 coordinates.
Gene Name 2 X-box Binding Protein 1
Gene Summary 2 This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome22
Locus 2 22q12
Coordinates 2 This gene maps to 29190547-29196560 in GRCh37 coordinates.
Associated Diseases Lung Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-XBP1/UTRN-13246-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-XBP1/UTRN-13246-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-XBP1/UTRN-13246-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-XBP1/UTRN-13246-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-XBP1/UTRN-13246-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-XBP1/UTRN-13246-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-XBP1/UTRN-13246-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-XBP1/UTRN-13246-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-XBP1/UTRN-13246-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-XBP1/UTRN-13246-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-XBP1/UTRN-13246-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-XBP1/UTRN-13246-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-XBP1/UTRN-13246-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-XBP1/UTRN-13246-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-XBP1/UTRN-13246-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-XBP1/UTRN-13246-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-XBP1/UTRN-13246-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-XBP1/UTRN-13246-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-XBP1/UTRN-13246-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-XBP1/UTRN-13246-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-XBP1/UTRN-13246-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-XBP1/UTRN-13246-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-XBP1/UTRN-13246-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-XBP1/UTRN-13246-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-XBP1/UTRN-13246-AQAQ 467nm;467nm 418nm;418nm

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