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VIM-LAMA4 Gene Fusion FISH Probe

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Catalog: GFFP-VIM/LAMA4-15738
Classification: Gene Fusion FISH Probes
Description: The VIM-LAMA4 Gene Fusion FISH Probe can detect the fusion of ABCA5 and BCAS3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: VIM-LAMA4 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Laminin Subunit Alpha 4
Gene Summary 1 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Chromosome 1 Chromosome 6
Locus 1 6q21
Coordinates 1 This gene maps to 112429133-112575828in GRCh37 coordinates.
Gene Name 2 Vimentin
Gene Summary 2 This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]
Chromosome 2 Chromosome10
Locus 2 10p13
Coordinates 2 This gene maps to 17270257-17279592 in GRCh37 coordinates.
Associated Diseases Skin Cutaneous Melanoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-VIM/LAMA4-15738-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-VIM/LAMA4-15738-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-VIM/LAMA4-15738-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-VIM/LAMA4-15738-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-VIM/LAMA4-15738-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-VIM/LAMA4-15738-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-VIM/LAMA4-15738-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-VIM/LAMA4-15738-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-VIM/LAMA4-15738-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-VIM/LAMA4-15738-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-VIM/LAMA4-15738-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-VIM/LAMA4-15738-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-VIM/LAMA4-15738-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-VIM/LAMA4-15738-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-VIM/LAMA4-15738-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-VIM/LAMA4-15738-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-VIM/LAMA4-15738-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-VIM/LAMA4-15738-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-VIM/LAMA4-15738-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-VIM/LAMA4-15738-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-VIM/LAMA4-15738-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-VIM/LAMA4-15738-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-VIM/LAMA4-15738-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-VIM/LAMA4-15738-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-VIM/LAMA4-15738-AQAQ 467nm;467nm 418nm;418nm

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