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TOP2B-NGLY1 Gene Fusion FISH Probe

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Catalog: GFFP-TOP2B/NGLY1-12242
Classification: Gene Fusion FISH Probes
Description: The TOP2B-NGLY1 Gene Fusion FISH Probecan detect the fusion of TOP2B and NGLY1 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: TOP2B-NGLY1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 DNA Topoisomerase II Beta
Gene Summary 1 This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Chromosome 1 Chromosome 3
Locus 1 3p24.2
Coordinates 1 This gene maps to 25639474-25705788 in GRCh37 coordinates.
Gene Name 2 N-glycanase 1
Gene Summary 2 This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Chromosome 2 Chromosome3
Locus 2 3p24.2
Coordinates 2 This gene maps to 25760434-25831530 in GRCh37 coordinates.
Associated Diseases Bladder Urothelial Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-TOP2B/NGLY1-12242-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-TOP2B/NGLY1-12242-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-TOP2B/NGLY1-12242-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-TOP2B/NGLY1-12242-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-TOP2B/NGLY1-12242-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-TOP2B/NGLY1-12242-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-TOP2B/NGLY1-12242-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-TOP2B/NGLY1-12242-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-TOP2B/NGLY1-12242-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-TOP2B/NGLY1-12242-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-TOP2B/NGLY1-12242-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-TOP2B/NGLY1-12242-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-TOP2B/NGLY1-12242-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-TOP2B/NGLY1-12242-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-TOP2B/NGLY1-12242-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-TOP2B/NGLY1-12242-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-TOP2B/NGLY1-12242-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-TOP2B/NGLY1-12242-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-TOP2B/NGLY1-12242-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-TOP2B/NGLY1-12242-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-TOP2B/NGLY1-12242-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-TOP2B/NGLY1-12242-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-TOP2B/NGLY1-12242-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-TOP2B/NGLY1-12242-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-TOP2B/NGLY1-12242-AQAQ 467nm;467nm 418nm;418nm

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