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TMPRSS2-ERG Gene Fusion FISH Probe

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Catalog: GFFP-TMPRSS2/ERG-15669
Classification: Gene Fusion FISH Probes
Description: The TMPRSS2-ERG Gene Fusion FISH Probe can detect the fusion of ABCA5 and BCAS3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: TMPRSS2-ERG Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 ERG, ETS Transcription Factor
Gene Summary 1 This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Chromosome 1 Chromosome 21
Locus 1 21q22.2
Coordinates 1 This gene maps to 39739182-40033618in GRCh37 coordinates.
Gene Name 2 Transmembrane Protease, Serine 2
Gene Summary 2 This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Chromosome 2 Chromosome21
Locus 2 21q22.3
Coordinates 2 This gene maps to 42836477-42880085 in GRCh37 coordinates.
Associated Diseases Prostate Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-TMPRSS2/ERG-15669-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-TMPRSS2/ERG-15669-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-TMPRSS2/ERG-15669-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-TMPRSS2/ERG-15669-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-TMPRSS2/ERG-15669-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-TMPRSS2/ERG-15669-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-TMPRSS2/ERG-15669-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-TMPRSS2/ERG-15669-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-TMPRSS2/ERG-15669-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-TMPRSS2/ERG-15669-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-TMPRSS2/ERG-15669-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-TMPRSS2/ERG-15669-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-TMPRSS2/ERG-15669-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-TMPRSS2/ERG-15669-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-TMPRSS2/ERG-15669-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-TMPRSS2/ERG-15669-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-TMPRSS2/ERG-15669-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-TMPRSS2/ERG-15669-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-TMPRSS2/ERG-15669-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-TMPRSS2/ERG-15669-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-TMPRSS2/ERG-15669-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-TMPRSS2/ERG-15669-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-TMPRSS2/ERG-15669-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-TMPRSS2/ERG-15669-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-TMPRSS2/ERG-15669-AQAQ 467nm;467nm 418nm;418nm

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