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TBL1XR1-RET Gene Fusion FISH Probe

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Catalog: GFFP-TBL1XR1/RET-12028
Classification: Gene Fusion FISH Probes
Description: The TBL1XR1-RET Gene Fusion FISH Probecan detect the fusion of TBL1XR1 and RET genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: TBL1XR1-RET Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Ret Proto-oncogene
Gene Summary 1 This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Chromosome 1 Chromosome 10
Locus 1 10q11.21
Coordinates 1 This gene maps to 43572516-43625797 in GRCh37 coordinates.
Gene Name 2 Transducin Beta Like 1 X-linked Receptor 1
Gene Summary 2 This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Chromosome 2 Chromosome3
Locus 2 3q26.32
Coordinates 2 This gene maps to 176738541-176915048 in GRCh37 coordinates.
Associated Diseases Thyroid Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-TBL1XR1/RET-12028-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-TBL1XR1/RET-12028-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-TBL1XR1/RET-12028-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-TBL1XR1/RET-12028-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-TBL1XR1/RET-12028-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-TBL1XR1/RET-12028-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-TBL1XR1/RET-12028-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-TBL1XR1/RET-12028-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-TBL1XR1/RET-12028-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-TBL1XR1/RET-12028-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-TBL1XR1/RET-12028-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-TBL1XR1/RET-12028-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-TBL1XR1/RET-12028-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-TBL1XR1/RET-12028-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-TBL1XR1/RET-12028-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-TBL1XR1/RET-12028-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-TBL1XR1/RET-12028-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-TBL1XR1/RET-12028-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-TBL1XR1/RET-12028-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-TBL1XR1/RET-12028-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-TBL1XR1/RET-12028-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-TBL1XR1/RET-12028-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-TBL1XR1/RET-12028-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-TBL1XR1/RET-12028-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-TBL1XR1/RET-12028-AQAQ 467nm;467nm 418nm;418nm

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