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STIM1-NUP98 Gene Fusion FISH Probe

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Catalog: GFFP-STIM1/NUP98-11378
Classification: Gene Fusion FISH Probes
Description: The STIM1-NUP98 Gene Fusion FISH Probecan detect the fusion of STIM1 and NUP98 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: STIM1-NUP98 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Nucleoporin 98
Gene Summary 1 Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Chromosome 1 Chromosome 11
Locus 1 11p15.4
Coordinates 1 This gene maps to 3696239-3819022 in GRCh37 coordinates.
Gene Name 2 Stromal Interaction Molecule 1
Gene Summary 2 This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome 2 Chromosome11
Locus 2 11p15.4
Coordinates 2 This gene maps to 3876932-4114440 in GRCh37 coordinates.
Associated Diseases Lung Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-STIM1/NUP98-11378-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-STIM1/NUP98-11378-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-STIM1/NUP98-11378-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-STIM1/NUP98-11378-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-STIM1/NUP98-11378-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-STIM1/NUP98-11378-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-STIM1/NUP98-11378-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-STIM1/NUP98-11378-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-STIM1/NUP98-11378-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-STIM1/NUP98-11378-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-STIM1/NUP98-11378-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-STIM1/NUP98-11378-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-STIM1/NUP98-11378-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-STIM1/NUP98-11378-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-STIM1/NUP98-11378-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-STIM1/NUP98-11378-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-STIM1/NUP98-11378-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-STIM1/NUP98-11378-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-STIM1/NUP98-11378-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-STIM1/NUP98-11378-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-STIM1/NUP98-11378-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-STIM1/NUP98-11378-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-STIM1/NUP98-11378-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-STIM1/NUP98-11378-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-STIM1/NUP98-11378-AQAQ 467nm;467nm 418nm;418nm

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