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SPEN-PLEKHM2 Gene Fusion FISH Probe

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Catalog: GFFP-SPEN/PLEKHM2-15591
Classification: Gene Fusion FISH Probes
Description: The SPEN-PLEKHM2 Gene Fusion FISH Probe can detect the fusion of ABCA5 and BCAS3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: SPEN-PLEKHM2 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Spen Family Transcriptional Repressor
Gene Summary 1 This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 1
Locus 1 1p36.21-p36.13
Coordinates 1 This gene maps to 16174358-16266950in GRCh37 coordinates.
Gene Name 2 Pleckstrin Homology And RUN Domain Containing M2
Gene Summary 2 This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Chromosome 2 Chromosome1
Locus 2 1p36.21
Coordinates 2 This gene maps to 16010826-16061264 in GRCh37 coordinates.
Associated Diseases Sarcoma; Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-SPEN/PLEKHM2-15591-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-SPEN/PLEKHM2-15591-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-SPEN/PLEKHM2-15591-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-SPEN/PLEKHM2-15591-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-SPEN/PLEKHM2-15591-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-SPEN/PLEKHM2-15591-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-SPEN/PLEKHM2-15591-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-SPEN/PLEKHM2-15591-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-SPEN/PLEKHM2-15591-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-SPEN/PLEKHM2-15591-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-SPEN/PLEKHM2-15591-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-SPEN/PLEKHM2-15591-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-SPEN/PLEKHM2-15591-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-SPEN/PLEKHM2-15591-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-SPEN/PLEKHM2-15591-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-SPEN/PLEKHM2-15591-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-SPEN/PLEKHM2-15591-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-SPEN/PLEKHM2-15591-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-SPEN/PLEKHM2-15591-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-SPEN/PLEKHM2-15591-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-SPEN/PLEKHM2-15591-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-SPEN/PLEKHM2-15591-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-SPEN/PLEKHM2-15591-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-SPEN/PLEKHM2-15591-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-SPEN/PLEKHM2-15591-AQAQ 467nm;467nm 418nm;418nm

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