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SACS-MYO16 Gene Fusion FISH Probe

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Catalog: GFFP-SACS/MYO16-10533
Classification: Gene Fusion FISH Probes
Description: The SACS-MYO16 Gene Fusion FISH Probecan detect the fusion of SACS and MYO16 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: SACS-MYO16 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Myosin XVI
Gene Summary 1 This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]
Chromosome 1 Chromosome 13
Locus 1 13q33.3
Coordinates 1 This gene maps to 109248499-109860355 in GRCh37 coordinates.
Gene Name 2 Sacsin Molecular Chaperone
Gene Summary 2 This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome 2 Chromosome13
Locus 2 13q12.12
Coordinates 2 This gene maps to 23902964-24007841 in GRCh37 coordinates.
Associated Diseases Sarcoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-SACS/MYO16-10533-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-SACS/MYO16-10533-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-SACS/MYO16-10533-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-SACS/MYO16-10533-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-SACS/MYO16-10533-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-SACS/MYO16-10533-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-SACS/MYO16-10533-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-SACS/MYO16-10533-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-SACS/MYO16-10533-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-SACS/MYO16-10533-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-SACS/MYO16-10533-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-SACS/MYO16-10533-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-SACS/MYO16-10533-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-SACS/MYO16-10533-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-SACS/MYO16-10533-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-SACS/MYO16-10533-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-SACS/MYO16-10533-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-SACS/MYO16-10533-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-SACS/MYO16-10533-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-SACS/MYO16-10533-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-SACS/MYO16-10533-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-SACS/MYO16-10533-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-SACS/MYO16-10533-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-SACS/MYO16-10533-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-SACS/MYO16-10533-AQAQ 467nm;467nm 418nm;418nm

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