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S100A6-ERBB3 Gene Fusion FISH Probe

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Catalog: GFFP-S100A6/ERBB3-10543
Classification: Gene Fusion FISH Probes
Description: The S100A6-ERBB3 Gene Fusion FISH Probecan detect the fusion of S100A6 and ERBB3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: S100A6-ERBB3 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Erb-b2 Receptor Tyrosine Kinase 3
Gene Summary 1 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 12
Locus 1 12q13.2
Coordinates 1 This gene maps to 56473808-56497291 in GRCh37 coordinates.
Gene Name 2 S100 Calcium Binding Protein A6
Gene Summary 2 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome1
Locus 2 1q21.3
Coordinates 2 This gene maps to 153507075-153508717 in GRCh37 coordinates.
Associated Diseases Pancreatic Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-S100A6/ERBB3-10543-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-S100A6/ERBB3-10543-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-S100A6/ERBB3-10543-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-S100A6/ERBB3-10543-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-S100A6/ERBB3-10543-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-S100A6/ERBB3-10543-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-S100A6/ERBB3-10543-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-S100A6/ERBB3-10543-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-S100A6/ERBB3-10543-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-S100A6/ERBB3-10543-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-S100A6/ERBB3-10543-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-S100A6/ERBB3-10543-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-S100A6/ERBB3-10543-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-S100A6/ERBB3-10543-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-S100A6/ERBB3-10543-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-S100A6/ERBB3-10543-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-S100A6/ERBB3-10543-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-S100A6/ERBB3-10543-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-S100A6/ERBB3-10543-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-S100A6/ERBB3-10543-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-S100A6/ERBB3-10543-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-S100A6/ERBB3-10543-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-S100A6/ERBB3-10543-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-S100A6/ERBB3-10543-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-S100A6/ERBB3-10543-AQAQ 467nm;467nm 418nm;418nm

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