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RUNX1T1-RUNX1 Gene Fusion FISH Probe

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Catalog: GFFP-RUNX1T1/RUNX1-10218
Classification: Gene Fusion FISH Probes
Description: The RUNX1T1-RUNX1 Gene Fusion FISH Probecan detect the fusion of RUNX1T1 and RUNX1 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: RUNX1T1-RUNX1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Runt Related Transcription Factor 1
Gene Summary 1 Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 21
Locus 1 21q22.12
Coordinates 1 This gene maps to 36160097-36421595 in GRCh37 coordinates.
Gene Name 2 RUNX1 Translocation Partner 1
Gene Summary 2 This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Chromosome 2 Chromosome8
Locus 2 8q21.3
Coordinates 2 This gene maps to 92967194-93115454 in GRCh37 coordinates.
Associated Diseases Acute Myeloid Leukemia
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-RUNX1T1/RUNX1-10218-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-RUNX1T1/RUNX1-10218-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-RUNX1T1/RUNX1-10218-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-RUNX1T1/RUNX1-10218-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-RUNX1T1/RUNX1-10218-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-RUNX1T1/RUNX1-10218-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-RUNX1T1/RUNX1-10218-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-RUNX1T1/RUNX1-10218-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-RUNX1T1/RUNX1-10218-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-RUNX1T1/RUNX1-10218-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-RUNX1T1/RUNX1-10218-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-RUNX1T1/RUNX1-10218-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-RUNX1T1/RUNX1-10218-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-RUNX1T1/RUNX1-10218-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-RUNX1T1/RUNX1-10218-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-RUNX1T1/RUNX1-10218-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-RUNX1T1/RUNX1-10218-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-RUNX1T1/RUNX1-10218-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-RUNX1T1/RUNX1-10218-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-RUNX1T1/RUNX1-10218-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-RUNX1T1/RUNX1-10218-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-RUNX1T1/RUNX1-10218-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-RUNX1T1/RUNX1-10218-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-RUNX1T1/RUNX1-10218-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-RUNX1T1/RUNX1-10218-AQAQ 467nm;467nm 418nm;418nm

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