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ROCK1-B4GALT6 Gene Fusion FISH Probe

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Catalog: GFFP-ROCK1/B4GALT6-14525
Classification: Gene Fusion FISH Probes
Description: The ROCK1-B4GALT6 Gene Fusion FISH Probecan detect the fusion of ROCK1 and B4GALT6 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: ROCK1-B4GALT6 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Rho Associated Coiled-coil Containing Protein Kinase 1
Gene Summary 1 This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Chromosome 1 Chromosome 18
Locus 1 18q11.1
Coordinates 1 This gene maps to 18529702-18691812 in GRCh37 coordinates.
Gene Name 2 Beta-1,4-galactosyltransferase 6
Gene Summary 2 This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome18
Locus 2 18q12.1
Coordinates 2 This gene maps to 29202208-29264686 in GRCh37 coordinates.
Associated Diseases Head And Neck Squamous Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-ROCK1/B4GALT6-14525-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-ROCK1/B4GALT6-14525-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-ROCK1/B4GALT6-14525-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-ROCK1/B4GALT6-14525-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-ROCK1/B4GALT6-14525-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-ROCK1/B4GALT6-14525-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-ROCK1/B4GALT6-14525-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-ROCK1/B4GALT6-14525-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-ROCK1/B4GALT6-14525-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-ROCK1/B4GALT6-14525-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-ROCK1/B4GALT6-14525-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-ROCK1/B4GALT6-14525-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-ROCK1/B4GALT6-14525-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-ROCK1/B4GALT6-14525-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-ROCK1/B4GALT6-14525-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-ROCK1/B4GALT6-14525-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-ROCK1/B4GALT6-14525-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-ROCK1/B4GALT6-14525-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-ROCK1/B4GALT6-14525-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-ROCK1/B4GALT6-14525-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-ROCK1/B4GALT6-14525-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-ROCK1/B4GALT6-14525-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-ROCK1/B4GALT6-14525-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-ROCK1/B4GALT6-14525-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-ROCK1/B4GALT6-14525-AQAQ 467nm;467nm 418nm;418nm

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