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RNF121-ESRRG Gene Fusion FISH Probe

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Catalog: GFFP-RNF121/ESRRG-10094
Classification: Gene Fusion FISH Probes
Description: The RNF121-ESRRG Gene Fusion FISH Probecan detect the fusion of RNF121 and ESRRG genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: RNF121-ESRRG Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Estrogen Related Receptor Gamma
Gene Summary 1 This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Chromosome 1 Chromosome 1
Locus 1 1q41
Coordinates 1 This gene maps to 216676587-217311097 in GRCh37 coordinates.
Gene Name 2 Ring Finger Protein 121
Gene Summary 2 The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Chromosome 2 Chromosome11
Locus 2 11q13.4
Coordinates 2 This gene maps to 71639767-71708643 in GRCh37 coordinates.
Associated Diseases Breast Invasive Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-RNF121/ESRRG-10094-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-RNF121/ESRRG-10094-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-RNF121/ESRRG-10094-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-RNF121/ESRRG-10094-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-RNF121/ESRRG-10094-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-RNF121/ESRRG-10094-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-RNF121/ESRRG-10094-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-RNF121/ESRRG-10094-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-RNF121/ESRRG-10094-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-RNF121/ESRRG-10094-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-RNF121/ESRRG-10094-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-RNF121/ESRRG-10094-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-RNF121/ESRRG-10094-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-RNF121/ESRRG-10094-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-RNF121/ESRRG-10094-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-RNF121/ESRRG-10094-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-RNF121/ESRRG-10094-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-RNF121/ESRRG-10094-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-RNF121/ESRRG-10094-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-RNF121/ESRRG-10094-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-RNF121/ESRRG-10094-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-RNF121/ESRRG-10094-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-RNF121/ESRRG-10094-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-RNF121/ESRRG-10094-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-RNF121/ESRRG-10094-AQAQ 467nm;467nm 418nm;418nm

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