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RAP1GAP-CELA3B Gene Fusion FISH Probe

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Catalog: GFFP-RAP1GAP/CELA3B-09752
Classification: Gene Fusion FISH Probes
Description: The RAP1GAP-CELA3B Gene Fusion FISH Probecan detect the fusion of RAP1GAP and CELA3B genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: RAP1GAP-CELA3B Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 RAP1 GTPase Activating Protein
Gene Summary 1 This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Chromosome 1 Chromosome 1
Locus 1 1p36.12
Coordinates 1 This gene maps to 21922707-21995856 in GRCh37 coordinates.
Gene Name 2 Chymotrypsin Like Elastase Family Member 3B
Gene Summary 2 Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Chromosome 2 Chromosome1
Locus 2 1p36.12
Coordinates 2 This gene maps to 22303417-22315847 in GRCh37 coordinates.
Associated Diseases Breast Invasive Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-RAP1GAP/CELA3B-09752-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-RAP1GAP/CELA3B-09752-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-RAP1GAP/CELA3B-09752-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-RAP1GAP/CELA3B-09752-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-RAP1GAP/CELA3B-09752-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-RAP1GAP/CELA3B-09752-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-RAP1GAP/CELA3B-09752-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-RAP1GAP/CELA3B-09752-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-RAP1GAP/CELA3B-09752-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-RAP1GAP/CELA3B-09752-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-RAP1GAP/CELA3B-09752-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-RAP1GAP/CELA3B-09752-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-RAP1GAP/CELA3B-09752-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-RAP1GAP/CELA3B-09752-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-RAP1GAP/CELA3B-09752-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-RAP1GAP/CELA3B-09752-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-RAP1GAP/CELA3B-09752-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-RAP1GAP/CELA3B-09752-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-RAP1GAP/CELA3B-09752-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-RAP1GAP/CELA3B-09752-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-RAP1GAP/CELA3B-09752-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-RAP1GAP/CELA3B-09752-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-RAP1GAP/CELA3B-09752-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-RAP1GAP/CELA3B-09752-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-RAP1GAP/CELA3B-09752-AQAQ 467nm;467nm 418nm;418nm

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