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PRICKLE1-FGD4 Gene Fusion FISH Probe

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Catalog: GFFP-PRICKLE1/FGD4-09183
Classification: Gene Fusion FISH Probes
Description: The PRICKLE1-FGD4 Gene Fusion FISH Probecan detect the fusion of PRICKLE1 and FGD4 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: PRICKLE1-FGD4 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 FYVE, RhoGEF And PH Domain Containing 4
Gene Summary 1 This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Chromosome 1 Chromosome 12
Locus 1 12p11.21
Coordinates 1 This gene maps to 32655040-32798984 in GRCh37 coordinates.
Gene Name 2 Prickle Planar Cell Polarity Protein 1
Gene Summary 2 This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Chromosome 2 Chromosome12
Locus 2 12q12
Coordinates 2 This gene maps to 42852139-42983572 in GRCh37 coordinates.
Associated Diseases Breast Invasive Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-PRICKLE1/FGD4-09183-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-PRICKLE1/FGD4-09183-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-PRICKLE1/FGD4-09183-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-PRICKLE1/FGD4-09183-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-PRICKLE1/FGD4-09183-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-PRICKLE1/FGD4-09183-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-PRICKLE1/FGD4-09183-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-PRICKLE1/FGD4-09183-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-PRICKLE1/FGD4-09183-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-PRICKLE1/FGD4-09183-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-PRICKLE1/FGD4-09183-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-PRICKLE1/FGD4-09183-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-PRICKLE1/FGD4-09183-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-PRICKLE1/FGD4-09183-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-PRICKLE1/FGD4-09183-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-PRICKLE1/FGD4-09183-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-PRICKLE1/FGD4-09183-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-PRICKLE1/FGD4-09183-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-PRICKLE1/FGD4-09183-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-PRICKLE1/FGD4-09183-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-PRICKLE1/FGD4-09183-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-PRICKLE1/FGD4-09183-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-PRICKLE1/FGD4-09183-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-PRICKLE1/FGD4-09183-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-PRICKLE1/FGD4-09183-AQAQ 467nm;467nm 418nm;418nm

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