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PPP1R13B-ZP3 Gene Fusion FISH Probe

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Catalog: GFFP-PPP1R13B/ZP3-09296
Classification: Gene Fusion FISH Probes
Description: The PPP1R13B-ZP3 Gene Fusion FISH Probecan detect the fusion of PPP1R13B and ZP3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: PPP1R13B-ZP3 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Zona Pellucida Glycoprotein 3
Gene Summary 1 The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 7
Locus 1 7q11.23
Coordinates 1 This gene maps to 76026840-76071388 in GRCh37 coordinates.
Gene Name 2 Protein Phosphatase 1 Regulatory Subunit 13B
Gene Summary 2 This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome14
Locus 2 14q32.33
Coordinates 2 This gene maps to 104200087-104313927 in GRCh37 coordinates.
Associated Diseases Uterine Corpus Endometrial Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-PPP1R13B/ZP3-09296-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-PPP1R13B/ZP3-09296-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-PPP1R13B/ZP3-09296-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-PPP1R13B/ZP3-09296-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-PPP1R13B/ZP3-09296-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-PPP1R13B/ZP3-09296-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-PPP1R13B/ZP3-09296-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-PPP1R13B/ZP3-09296-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-PPP1R13B/ZP3-09296-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-PPP1R13B/ZP3-09296-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-PPP1R13B/ZP3-09296-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-PPP1R13B/ZP3-09296-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-PPP1R13B/ZP3-09296-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-PPP1R13B/ZP3-09296-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-PPP1R13B/ZP3-09296-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-PPP1R13B/ZP3-09296-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-PPP1R13B/ZP3-09296-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-PPP1R13B/ZP3-09296-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-PPP1R13B/ZP3-09296-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-PPP1R13B/ZP3-09296-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-PPP1R13B/ZP3-09296-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-PPP1R13B/ZP3-09296-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-PPP1R13B/ZP3-09296-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-PPP1R13B/ZP3-09296-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-PPP1R13B/ZP3-09296-AQAQ 467nm;467nm 418nm;418nm

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