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POLR2B-FIP1L1 Gene Fusion FISH Probe

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Catalog: GFFP-POLR2B/FIP1L1-15443
Classification: Gene Fusion FISH Probes
Description: The POLR2B-FIP1L1 Gene Fusion FISH Probe can detect the fusion of ABCA5 and BCAS3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: POLR2B-FIP1L1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 RNA Polymerase II Subunit B
Gene Summary 1 This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome 1 Chromosome 4
Locus 1 4q12
Coordinates 1 This gene maps to 57845108-57897334in GRCh37 coordinates.
Gene Name 2 Factor Interacting With PAPOLA And CPSF1
Gene Summary 2 This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Chromosome 2 Chromosome4
Locus 2 4q12
Coordinates 2 This gene maps to 54243819-54326103 in GRCh37 coordinates.
Associated Diseases Uterine Corpus Endometrial Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-POLR2B/FIP1L1-15443-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-POLR2B/FIP1L1-15443-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-POLR2B/FIP1L1-15443-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-POLR2B/FIP1L1-15443-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-POLR2B/FIP1L1-15443-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-POLR2B/FIP1L1-15443-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-POLR2B/FIP1L1-15443-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-POLR2B/FIP1L1-15443-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-POLR2B/FIP1L1-15443-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-POLR2B/FIP1L1-15443-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-POLR2B/FIP1L1-15443-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-POLR2B/FIP1L1-15443-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-POLR2B/FIP1L1-15443-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-POLR2B/FIP1L1-15443-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-POLR2B/FIP1L1-15443-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-POLR2B/FIP1L1-15443-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-POLR2B/FIP1L1-15443-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-POLR2B/FIP1L1-15443-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-POLR2B/FIP1L1-15443-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-POLR2B/FIP1L1-15443-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-POLR2B/FIP1L1-15443-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-POLR2B/FIP1L1-15443-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-POLR2B/FIP1L1-15443-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-POLR2B/FIP1L1-15443-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-POLR2B/FIP1L1-15443-AQAQ 467nm;467nm 418nm;418nm

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