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PLEC-EIF2AK2 Gene Fusion FISH Probe

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Catalog: GFFP-PLEC/EIF2AK2-08896
Classification: Gene Fusion FISH Probes
Description: The PLEC-EIF2AK2 Gene Fusion FISH Probecan detect the fusion of PLEC and EIF2AK2 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: PLEC-EIF2AK2 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Plectin
Gene Summary 1 Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
Chromosome 1 Chromosome 8
Locus 1 8q24.3
Coordinates 1 This gene maps to 144989320-145050913 in GRCh37 coordinates.
Gene Name 2 Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Gene Summary 2 The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome 2 Chromosome2
Locus 2 2p22.2
Coordinates 2 This gene maps to 37333698-37384190 in GRCh37 coordinates.
Associated Diseases Lung Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-PLEC/EIF2AK2-08896-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-PLEC/EIF2AK2-08896-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-PLEC/EIF2AK2-08896-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-PLEC/EIF2AK2-08896-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-PLEC/EIF2AK2-08896-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-PLEC/EIF2AK2-08896-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-PLEC/EIF2AK2-08896-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-PLEC/EIF2AK2-08896-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-PLEC/EIF2AK2-08896-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-PLEC/EIF2AK2-08896-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-PLEC/EIF2AK2-08896-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-PLEC/EIF2AK2-08896-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-PLEC/EIF2AK2-08896-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-PLEC/EIF2AK2-08896-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-PLEC/EIF2AK2-08896-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-PLEC/EIF2AK2-08896-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-PLEC/EIF2AK2-08896-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-PLEC/EIF2AK2-08896-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-PLEC/EIF2AK2-08896-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-PLEC/EIF2AK2-08896-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-PLEC/EIF2AK2-08896-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-PLEC/EIF2AK2-08896-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-PLEC/EIF2AK2-08896-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-PLEC/EIF2AK2-08896-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-PLEC/EIF2AK2-08896-AQAQ 467nm;467nm 418nm;418nm

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