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NOTCH2-SPAG17 Gene Fusion FISH Probe

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Catalog: GFFP-NOTCH2/SPAG17-14380
Classification: Gene Fusion FISH Probes
Description: The NOTCH2-SPAG17 Gene Fusion FISH Probecan detect the fusion of NOTCH2 and SPAG17 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: NOTCH2-SPAG17 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Notch 2
Gene Summary 1 This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Chromosome 1 Chromosome 1
Locus 1 1p12
Coordinates 1 This gene maps to 120454175-120612317 in GRCh37 coordinates.
Gene Name 2 Sperm Associated Antigen 17
Gene Summary 2 This gene encodes a central pair protein present in the axonemes of cells with a "9 + 2" organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. [provided by RefSeq, Feb 2017]
Chromosome 2 Chromosome1
Locus 2 1p12
Coordinates 2 This gene maps to 118496287-118727848 in GRCh37 coordinates.
Associated Diseases Head And Neck Squamous Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-NOTCH2/SPAG17-14380-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-NOTCH2/SPAG17-14380-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-NOTCH2/SPAG17-14380-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-NOTCH2/SPAG17-14380-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-NOTCH2/SPAG17-14380-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-NOTCH2/SPAG17-14380-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-NOTCH2/SPAG17-14380-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-NOTCH2/SPAG17-14380-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-NOTCH2/SPAG17-14380-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-NOTCH2/SPAG17-14380-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-NOTCH2/SPAG17-14380-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-NOTCH2/SPAG17-14380-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-NOTCH2/SPAG17-14380-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-NOTCH2/SPAG17-14380-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-NOTCH2/SPAG17-14380-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-NOTCH2/SPAG17-14380-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-NOTCH2/SPAG17-14380-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-NOTCH2/SPAG17-14380-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-NOTCH2/SPAG17-14380-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-NOTCH2/SPAG17-14380-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-NOTCH2/SPAG17-14380-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-NOTCH2/SPAG17-14380-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-NOTCH2/SPAG17-14380-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-NOTCH2/SPAG17-14380-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-NOTCH2/SPAG17-14380-AQAQ 467nm;467nm 418nm;418nm

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