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NOTCH1-MAPK1 Gene Fusion FISH Probe

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Catalog: GFFP-NOTCH1/MAPK1-14381
Classification: Gene Fusion FISH Probes
Description: The NOTCH1-MAPK1 Gene Fusion FISH Probecan detect the fusion of NOTCH1 and MAPK1 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: NOTCH1-MAPK1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Notch 1
Gene Summary 1 This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Chromosome 1 Chromosome 9
Locus 1 9q34.3
Coordinates 1 This gene maps to 139388895-139440238 in GRCh37 coordinates.
Gene Name 2 Mitogen-activated Protein Kinase 1
Gene Summary 2 This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Chromosome 2 Chromosome22
Locus 2 22q11.22
Coordinates 2 This gene maps to 22113946-22221970 in GRCh37 coordinates.
Associated Diseases Head And Neck Squamous Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-NOTCH1/MAPK1-14381-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-NOTCH1/MAPK1-14381-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-NOTCH1/MAPK1-14381-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-NOTCH1/MAPK1-14381-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-NOTCH1/MAPK1-14381-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-NOTCH1/MAPK1-14381-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-NOTCH1/MAPK1-14381-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-NOTCH1/MAPK1-14381-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-NOTCH1/MAPK1-14381-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-NOTCH1/MAPK1-14381-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-NOTCH1/MAPK1-14381-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-NOTCH1/MAPK1-14381-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-NOTCH1/MAPK1-14381-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-NOTCH1/MAPK1-14381-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-NOTCH1/MAPK1-14381-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-NOTCH1/MAPK1-14381-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-NOTCH1/MAPK1-14381-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-NOTCH1/MAPK1-14381-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-NOTCH1/MAPK1-14381-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-NOTCH1/MAPK1-14381-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-NOTCH1/MAPK1-14381-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-NOTCH1/MAPK1-14381-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-NOTCH1/MAPK1-14381-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-NOTCH1/MAPK1-14381-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-NOTCH1/MAPK1-14381-AQAQ 467nm;467nm 418nm;418nm

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