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MKL1-INPP5D Gene Fusion FISH Probe

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Catalog: GFFP-MKL1/INPP5D-07315
Classification: Gene Fusion FISH Probes
Description: The MKL1-INPP5D Gene Fusion FISH Probecan detect the fusion of MKL1 and INPP5D genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: MKL1-INPP5D Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Inositol Polyphosphate-5-phosphatase D
Gene Summary 1 This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome 1 Chromosome 2
Locus 1 2q37.1
Coordinates 1 This gene maps to 233925035-234116549 in GRCh37 coordinates.
Gene Name 2 Megakaryoblastic Leukemia (translocation) 1
Gene Summary 2 The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome 2 Chromosome22
Locus 2 22q13.1-q13.2
Coordinates 2 This gene maps to 40806291-41032690 in GRCh37 coordinates.
Associated Diseases Uterine Carcinosarcoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-MKL1/INPP5D-07315-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-MKL1/INPP5D-07315-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-MKL1/INPP5D-07315-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-MKL1/INPP5D-07315-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-MKL1/INPP5D-07315-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-MKL1/INPP5D-07315-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-MKL1/INPP5D-07315-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-MKL1/INPP5D-07315-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-MKL1/INPP5D-07315-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-MKL1/INPP5D-07315-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-MKL1/INPP5D-07315-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-MKL1/INPP5D-07315-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-MKL1/INPP5D-07315-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-MKL1/INPP5D-07315-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-MKL1/INPP5D-07315-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-MKL1/INPP5D-07315-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-MKL1/INPP5D-07315-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-MKL1/INPP5D-07315-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-MKL1/INPP5D-07315-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-MKL1/INPP5D-07315-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-MKL1/INPP5D-07315-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-MKL1/INPP5D-07315-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-MKL1/INPP5D-07315-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-MKL1/INPP5D-07315-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-MKL1/INPP5D-07315-AQAQ 467nm;467nm 418nm;418nm

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