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MAPK14-ANK1 Gene Fusion FISH Probe

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Catalog: GFFP-MAPK14/ANK1-14304
Classification: Gene Fusion FISH Probes
Description: The MAPK14-ANK1 Gene Fusion FISH Probecan detect the fusion of MAPK14 and ANK1 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: MAPK14-ANK1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Ankyrin 1
Gene Summary 1 Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Chromosome 1 Chromosome 8
Locus 1 8p11.21
Coordinates 1 This gene maps to 41510743-41754280 in GRCh37 coordinates.
Gene Name 2 Mitogen-activated Protein Kinase 14
Gene Summary 2 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome6
Locus 2 6p21.31
Coordinates 2 This gene maps to 35995453-36079013 in GRCh37 coordinates.
Associated Diseases Head And Neck Squamous Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-MAPK14/ANK1-14304-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-MAPK14/ANK1-14304-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-MAPK14/ANK1-14304-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-MAPK14/ANK1-14304-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-MAPK14/ANK1-14304-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-MAPK14/ANK1-14304-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-MAPK14/ANK1-14304-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-MAPK14/ANK1-14304-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-MAPK14/ANK1-14304-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-MAPK14/ANK1-14304-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-MAPK14/ANK1-14304-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-MAPK14/ANK1-14304-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-MAPK14/ANK1-14304-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-MAPK14/ANK1-14304-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-MAPK14/ANK1-14304-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-MAPK14/ANK1-14304-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-MAPK14/ANK1-14304-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-MAPK14/ANK1-14304-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-MAPK14/ANK1-14304-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-MAPK14/ANK1-14304-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-MAPK14/ANK1-14304-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-MAPK14/ANK1-14304-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-MAPK14/ANK1-14304-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-MAPK14/ANK1-14304-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-MAPK14/ANK1-14304-AQAQ 467nm;467nm 418nm;418nm

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