KRT5-HLA-DRA Gene Fusion FISH Probe
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Catalog: |
GFFP-KRT5/HLA/DRA-14246 |
Classification: |
Gene Fusion FISH Probes |
Description: |
The KRT5-HLA-DRA Gene Fusion FISH Probecan detect the fusion of KRT5 and HLA-DRA genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Category: |
Gene Fusion FISH Probes |
Application: |
KRT5-HLA-DRA Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Probe Kits Volume (µL): |
40 μL |
Quantity: |
20 Tests |
Hybridization Solution (µL): |
200 μL |
Turnaround Time: |
7-10 Business Days |
Shipping Time: |
1-2 Day Expedited Shipping |
Storage Conditions: |
Store at -20℃ and avoid light; |
Shipping Conditions: |
-20℃ |
Gene Details
Gene Name 1 |
Major Histocompatibility Complex, Class II, DR Alpha |
Gene Summary 1 |
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008] |
Chromosome 1 |
Chromosome 6_mann_hap4 |
Locus 1 |
6p21.32 |
Coordinates 1 |
This gene maps to 3749678-3754894 in GRCh37 coordinates. |
Gene Name 2 |
Keratin 5 |
Gene Summary 2 |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
Chromosome 2 |
Chromosome12 |
Locus 2 |
12q13.13 |
Coordinates 2 |
This gene maps to 52908358-52914243 in GRCh37 coordinates. |
Associated Diseases |
Head And Neck Squamous Cell Carcinoma |
Species |
Human |
Dye Colors:
RE
RE
RE
OR
RE
GO
RE
GR
RE
AQ
OR
RE
OR
OR
OR
GO
OR
GR
OR
AQ
GO
RE
GO
OR
GO
GO
GO
GR
GO
AQ
GR
RE
GR
OR
GR
GO
GR
GR
GR
AQ
AQ
RE
AQ
OR
AQ
GO
AQ
GR
AQ
AQ
Order Sheet
Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
1 |
RE; RE
|
GFFP-KRT5/HLA/DRA-14246-RERE |
599nm;599nm |
580nm;580nm |
|
2 |
RE; OR
|
GFFP-KRT5/HLA/DRA-14246-REOR |
599nm;573nm |
580nm;548nm |
|
3 |
RE; GO
|
GFFP-KRT5/HLA/DRA-14246-REGO |
599nm;551nm |
580nm;525nm |
|
4 |
RE; GR
|
GFFP-KRT5/HLA/DRA-14246-REGR |
599nm;515nm |
580nm;491nm |
|
5 |
RE; AQ
|
GFFP-KRT5/HLA/DRA-14246-REAQ |
599nm;467nm |
580nm;418nm |
|
6 |
OR; RE
|
GFFP-KRT5/HLA/DRA-14246-ORRE |
573nm;599nm |
548nm;580nm |
|
7 |
OR; OR
|
GFFP-KRT5/HLA/DRA-14246-OROR |
573nm;573nm |
548nm;548nm |
|
8 |
OR; GO
|
GFFP-KRT5/HLA/DRA-14246-ORGO |
573nm;551nm |
548nm;525nm |
|
9 |
OR; GR
|
GFFP-KRT5/HLA/DRA-14246-ORGR |
573nm;515nm |
548nm;491nm |
|
10 |
OR; AQ
|
GFFP-KRT5/HLA/DRA-14246-ORAQ |
573nm;467nm |
548nm;418nm |
|
11 |
GO; RE
|
GFFP-KRT5/HLA/DRA-14246-GORE |
551nm;599nm |
525nm;580nm |
|
12 |
GO; OR
|
GFFP-KRT5/HLA/DRA-14246-GOOR |
551nm;573nm |
525nm;548nm |
|
13 |
GO; GO
|
GFFP-KRT5/HLA/DRA-14246-GOGO |
551nm;551nm |
525nm;525nm |
|
14 |
GO; GR
|
GFFP-KRT5/HLA/DRA-14246-GOGR |
551nm;515nm |
525nm;491nm |
|
15 |
GO; AQ
|
GFFP-KRT5/HLA/DRA-14246-GOAQ |
551nm;467nm |
525nm;418nm |
|
16 |
GR; RE
|
GFFP-KRT5/HLA/DRA-14246-GRRE |
515nm;599nm |
491nm;580nm |
|
17 |
GR; OR
|
GFFP-KRT5/HLA/DRA-14246-GROR |
515nm;573nm |
491nm;548nm |
|
18 |
GR; GO
|
GFFP-KRT5/HLA/DRA-14246-GRGO |
515nm;551nm |
491nm;525nm |
|
19 |
GR; GR
|
GFFP-KRT5/HLA/DRA-14246-GRGR |
515nm;515nm |
491nm;491nm |
|
20 |
GR; AQ
|
GFFP-KRT5/HLA/DRA-14246-GRAQ |
515nm;467nm |
491nm;418nm |
|
21 |
AQ; RE
|
GFFP-KRT5/HLA/DRA-14246-AQRE |
467nm;599nm |
418nm;580nm |
|
22 |
AQ; OR
|
GFFP-KRT5/HLA/DRA-14246-AQOR |
467nm;573nm |
418nm;548nm |
|
23 |
AQ; GO
|
GFFP-KRT5/HLA/DRA-14246-AQGO |
467nm;551nm |
418nm;525nm |
|
24 |
AQ; GR
|
GFFP-KRT5/HLA/DRA-14246-AQGR |
467nm;515nm |
418nm;491nm |
|
25 |
AQ; AQ
|
GFFP-KRT5/HLA/DRA-14246-AQAQ |
467nm;467nm |
418nm;418nm |
|
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