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IGFBP3-CLCN3 Gene Fusion FISH Probe

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Catalog: GFFP-IGFBP3/CLCN3-05563
Classification: Gene Fusion FISH Probes
Description: The IGFBP3-CLCN3 Gene Fusion FISH Probecan detect the fusion of IGFBP3 and CLCN3 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: IGFBP3-CLCN3 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Chloride Voltage-gated Channel 3
Gene Summary 1 This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Chromosome 1 Chromosome 4
Locus 1 4q33
Coordinates 1 This gene maps to 170541671-170644338 in GRCh37 coordinates.
Gene Name 2 Insulin Like Growth Factor Binding Protein 3
Gene Summary 2 This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome7
Locus 2 7p12.3
Coordinates 2 This gene maps to 45951843-45960871 in GRCh37 coordinates.
Associated Diseases Kidney Renal Clear Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-IGFBP3/CLCN3-05563-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-IGFBP3/CLCN3-05563-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-IGFBP3/CLCN3-05563-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-IGFBP3/CLCN3-05563-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-IGFBP3/CLCN3-05563-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-IGFBP3/CLCN3-05563-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-IGFBP3/CLCN3-05563-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-IGFBP3/CLCN3-05563-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-IGFBP3/CLCN3-05563-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-IGFBP3/CLCN3-05563-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-IGFBP3/CLCN3-05563-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-IGFBP3/CLCN3-05563-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-IGFBP3/CLCN3-05563-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-IGFBP3/CLCN3-05563-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-IGFBP3/CLCN3-05563-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-IGFBP3/CLCN3-05563-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-IGFBP3/CLCN3-05563-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-IGFBP3/CLCN3-05563-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-IGFBP3/CLCN3-05563-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-IGFBP3/CLCN3-05563-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-IGFBP3/CLCN3-05563-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-IGFBP3/CLCN3-05563-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-IGFBP3/CLCN3-05563-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-IGFBP3/CLCN3-05563-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-IGFBP3/CLCN3-05563-AQAQ 467nm;467nm 418nm;418nm

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