HNRNPH1-ERG Gene Fusion FISH Probe
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Catalog: |
GFFP-HNRNPH1/ERG-05403 |
Classification: |
Gene Fusion FISH Probes |
Description: |
The HNRNPH1-ERG Gene Fusion FISH Probecan detect the fusion of HNRNPH1 and ERG genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Category: |
Gene Fusion FISH Probes |
Application: |
HNRNPH1-ERG Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Probe Kits Volume (µL): |
40 μL |
Quantity: |
20 Tests |
Hybridization Solution (µL): |
200 μL |
Turnaround Time: |
7-10 Business Days |
Shipping Time: |
1-2 Day Expedited Shipping |
Storage Conditions: |
Store at -20℃ and avoid light; |
Shipping Conditions: |
-20℃ |
Gene Details
Gene Name 1 |
ERG, ETS Transcription Factor |
Gene Summary 1 |
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] |
Chromosome 1 |
Chromosome 21 |
Locus 1 |
21q22.2 |
Coordinates 1 |
This gene maps to 39739182-40033618 in GRCh37 coordinates. |
Gene Name 2 |
Heterogeneous Nuclear Ribonucleoprotein H1 |
Gene Summary 2 |
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012] |
Chromosome 2 |
Chromosome5 |
Locus 2 |
5q35.3 |
Coordinates 2 |
This gene maps to 179041178-179050722 in GRCh37 coordinates. |
Associated Diseases |
Acute Myeloid Leukemia |
Species |
Human |
Dye Colors:
RE
RE
RE
OR
RE
GO
RE
GR
RE
AQ
OR
RE
OR
OR
OR
GO
OR
GR
OR
AQ
GO
RE
GO
OR
GO
GO
GO
GR
GO
AQ
GR
RE
GR
OR
GR
GO
GR
GR
GR
AQ
AQ
RE
AQ
OR
AQ
GO
AQ
GR
AQ
AQ
Order Sheet
Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
1 |
RE; RE
|
GFFP-HNRNPH1/ERG-05403-RERE |
599nm;599nm |
580nm;580nm |
|
2 |
RE; OR
|
GFFP-HNRNPH1/ERG-05403-REOR |
599nm;573nm |
580nm;548nm |
|
3 |
RE; GO
|
GFFP-HNRNPH1/ERG-05403-REGO |
599nm;551nm |
580nm;525nm |
|
4 |
RE; GR
|
GFFP-HNRNPH1/ERG-05403-REGR |
599nm;515nm |
580nm;491nm |
|
5 |
RE; AQ
|
GFFP-HNRNPH1/ERG-05403-REAQ |
599nm;467nm |
580nm;418nm |
|
6 |
OR; RE
|
GFFP-HNRNPH1/ERG-05403-ORRE |
573nm;599nm |
548nm;580nm |
|
7 |
OR; OR
|
GFFP-HNRNPH1/ERG-05403-OROR |
573nm;573nm |
548nm;548nm |
|
8 |
OR; GO
|
GFFP-HNRNPH1/ERG-05403-ORGO |
573nm;551nm |
548nm;525nm |
|
9 |
OR; GR
|
GFFP-HNRNPH1/ERG-05403-ORGR |
573nm;515nm |
548nm;491nm |
|
10 |
OR; AQ
|
GFFP-HNRNPH1/ERG-05403-ORAQ |
573nm;467nm |
548nm;418nm |
|
11 |
GO; RE
|
GFFP-HNRNPH1/ERG-05403-GORE |
551nm;599nm |
525nm;580nm |
|
12 |
GO; OR
|
GFFP-HNRNPH1/ERG-05403-GOOR |
551nm;573nm |
525nm;548nm |
|
13 |
GO; GO
|
GFFP-HNRNPH1/ERG-05403-GOGO |
551nm;551nm |
525nm;525nm |
|
14 |
GO; GR
|
GFFP-HNRNPH1/ERG-05403-GOGR |
551nm;515nm |
525nm;491nm |
|
15 |
GO; AQ
|
GFFP-HNRNPH1/ERG-05403-GOAQ |
551nm;467nm |
525nm;418nm |
|
16 |
GR; RE
|
GFFP-HNRNPH1/ERG-05403-GRRE |
515nm;599nm |
491nm;580nm |
|
17 |
GR; OR
|
GFFP-HNRNPH1/ERG-05403-GROR |
515nm;573nm |
491nm;548nm |
|
18 |
GR; GO
|
GFFP-HNRNPH1/ERG-05403-GRGO |
515nm;551nm |
491nm;525nm |
|
19 |
GR; GR
|
GFFP-HNRNPH1/ERG-05403-GRGR |
515nm;515nm |
491nm;491nm |
|
20 |
GR; AQ
|
GFFP-HNRNPH1/ERG-05403-GRAQ |
515nm;467nm |
491nm;418nm |
|
21 |
AQ; RE
|
GFFP-HNRNPH1/ERG-05403-AQRE |
467nm;599nm |
418nm;580nm |
|
22 |
AQ; OR
|
GFFP-HNRNPH1/ERG-05403-AQOR |
467nm;573nm |
418nm;548nm |
|
23 |
AQ; GO
|
GFFP-HNRNPH1/ERG-05403-AQGO |
467nm;551nm |
418nm;525nm |
|
24 |
AQ; GR
|
GFFP-HNRNPH1/ERG-05403-AQGR |
467nm;515nm |
418nm;491nm |
|
25 |
AQ; AQ
|
GFFP-HNRNPH1/ERG-05403-AQAQ |
467nm;467nm |
418nm;418nm |
|
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