HLA-B-CFB Gene Fusion FISH Probe
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Catalog: |
GFFP-HLA/B/CFB-05461 |
Classification: |
Gene Fusion FISH Probes |
Description: |
The HLA-B-CFB Gene Fusion FISH Probecan detect the fusion of HLA-B and CFB genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Category: |
Gene Fusion FISH Probes |
Application: |
HLA-B-CFB Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Probe Kits Volume (µL): |
40 μL |
Quantity: |
20 Tests |
Hybridization Solution (µL): |
200 μL |
Turnaround Time: |
7-10 Business Days |
Shipping Time: |
1-2 Day Expedited Shipping |
Storage Conditions: |
Store at -20℃ and avoid light; |
Shipping Conditions: |
-20℃ |
Gene Details
Gene Name 1 |
Complement Factor B |
Gene Summary 1 |
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008] |
Chromosome 1 |
Chromosome 6_dbb_hap3 |
Locus 1 |
6p21.33 |
Coordinates 1 |
This gene maps to 3199308-3205449 in GRCh37 coordinates. |
Gene Name 2 |
Major Histocompatibility Complex, Class I, B |
Gene Summary 2 |
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] |
Chromosome 2 |
Chromosome6_mcf_hap5 |
Locus 2 |
6p21.33 |
Coordinates 2 |
This gene maps to 2701428-2704782 in GRCh37 coordinates. |
Associated Diseases |
Mesothelioma |
Species |
Human |
Dye Colors:
RE
RE
RE
OR
RE
GO
RE
GR
RE
AQ
OR
RE
OR
OR
OR
GO
OR
GR
OR
AQ
GO
RE
GO
OR
GO
GO
GO
GR
GO
AQ
GR
RE
GR
OR
GR
GO
GR
GR
GR
AQ
AQ
RE
AQ
OR
AQ
GO
AQ
GR
AQ
AQ
Order Sheet
Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
1 |
RE; RE
|
GFFP-HLA/B/CFB-05461-RERE |
599nm;599nm |
580nm;580nm |
|
2 |
RE; OR
|
GFFP-HLA/B/CFB-05461-REOR |
599nm;573nm |
580nm;548nm |
|
3 |
RE; GO
|
GFFP-HLA/B/CFB-05461-REGO |
599nm;551nm |
580nm;525nm |
|
4 |
RE; GR
|
GFFP-HLA/B/CFB-05461-REGR |
599nm;515nm |
580nm;491nm |
|
5 |
RE; AQ
|
GFFP-HLA/B/CFB-05461-REAQ |
599nm;467nm |
580nm;418nm |
|
6 |
OR; RE
|
GFFP-HLA/B/CFB-05461-ORRE |
573nm;599nm |
548nm;580nm |
|
7 |
OR; OR
|
GFFP-HLA/B/CFB-05461-OROR |
573nm;573nm |
548nm;548nm |
|
8 |
OR; GO
|
GFFP-HLA/B/CFB-05461-ORGO |
573nm;551nm |
548nm;525nm |
|
9 |
OR; GR
|
GFFP-HLA/B/CFB-05461-ORGR |
573nm;515nm |
548nm;491nm |
|
10 |
OR; AQ
|
GFFP-HLA/B/CFB-05461-ORAQ |
573nm;467nm |
548nm;418nm |
|
11 |
GO; RE
|
GFFP-HLA/B/CFB-05461-GORE |
551nm;599nm |
525nm;580nm |
|
12 |
GO; OR
|
GFFP-HLA/B/CFB-05461-GOOR |
551nm;573nm |
525nm;548nm |
|
13 |
GO; GO
|
GFFP-HLA/B/CFB-05461-GOGO |
551nm;551nm |
525nm;525nm |
|
14 |
GO; GR
|
GFFP-HLA/B/CFB-05461-GOGR |
551nm;515nm |
525nm;491nm |
|
15 |
GO; AQ
|
GFFP-HLA/B/CFB-05461-GOAQ |
551nm;467nm |
525nm;418nm |
|
16 |
GR; RE
|
GFFP-HLA/B/CFB-05461-GRRE |
515nm;599nm |
491nm;580nm |
|
17 |
GR; OR
|
GFFP-HLA/B/CFB-05461-GROR |
515nm;573nm |
491nm;548nm |
|
18 |
GR; GO
|
GFFP-HLA/B/CFB-05461-GRGO |
515nm;551nm |
491nm;525nm |
|
19 |
GR; GR
|
GFFP-HLA/B/CFB-05461-GRGR |
515nm;515nm |
491nm;491nm |
|
20 |
GR; AQ
|
GFFP-HLA/B/CFB-05461-GRAQ |
515nm;467nm |
491nm;418nm |
|
21 |
AQ; RE
|
GFFP-HLA/B/CFB-05461-AQRE |
467nm;599nm |
418nm;580nm |
|
22 |
AQ; OR
|
GFFP-HLA/B/CFB-05461-AQOR |
467nm;573nm |
418nm;548nm |
|
23 |
AQ; GO
|
GFFP-HLA/B/CFB-05461-AQGO |
467nm;551nm |
418nm;525nm |
|
24 |
AQ; GR
|
GFFP-HLA/B/CFB-05461-AQGR |
467nm;515nm |
418nm;491nm |
|
25 |
AQ; AQ
|
GFFP-HLA/B/CFB-05461-AQAQ |
467nm;467nm |
418nm;418nm |
|
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