HLA-B-CBS Gene Fusion FISH Probe
Add to Cart
Catalog: |
GFFP-HLA/B/CBS-05464 |
Classification: |
Gene Fusion FISH Probes |
Description: |
The HLA-B-CBS Gene Fusion FISH Probecan detect the fusion of HLA-B and CBS genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Category: |
Gene Fusion FISH Probes |
Application: |
HLA-B-CBS Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Probe Kits Volume (µL): |
40 μL |
Quantity: |
20 Tests |
Hybridization Solution (µL): |
200 μL |
Turnaround Time: |
7-10 Business Days |
Shipping Time: |
1-2 Day Expedited Shipping |
Storage Conditions: |
Store at -20℃ and avoid light; |
Shipping Conditions: |
-20℃ |
Gene Details
Gene Name 1 |
Cystathionine-beta-synthase |
Gene Summary 1 |
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016] |
Chromosome 1 |
Chromosome 21 |
Locus 1 |
21q22.3 |
Coordinates 1 |
This gene maps to 44473300-44496472 in GRCh37 coordinates. |
Gene Name 2 |
Major Histocompatibility Complex, Class I, B |
Gene Summary 2 |
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] |
Chromosome 2 |
Chromosome6_mcf_hap5 |
Locus 2 |
6p21.33 |
Coordinates 2 |
This gene maps to 2701428-2704782 in GRCh37 coordinates. |
Associated Diseases |
Uterine Corpus Endometrial Carcinoma |
Species |
Human |
Dye Colors:
RE
RE
RE
OR
RE
GO
RE
GR
RE
AQ
OR
RE
OR
OR
OR
GO
OR
GR
OR
AQ
GO
RE
GO
OR
GO
GO
GO
GR
GO
AQ
GR
RE
GR
OR
GR
GO
GR
GR
GR
AQ
AQ
RE
AQ
OR
AQ
GO
AQ
GR
AQ
AQ
Order Sheet
Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
1 |
RE; RE
|
GFFP-HLA/B/CBS-05464-RERE |
599nm;599nm |
580nm;580nm |
|
2 |
RE; OR
|
GFFP-HLA/B/CBS-05464-REOR |
599nm;573nm |
580nm;548nm |
|
3 |
RE; GO
|
GFFP-HLA/B/CBS-05464-REGO |
599nm;551nm |
580nm;525nm |
|
4 |
RE; GR
|
GFFP-HLA/B/CBS-05464-REGR |
599nm;515nm |
580nm;491nm |
|
5 |
RE; AQ
|
GFFP-HLA/B/CBS-05464-REAQ |
599nm;467nm |
580nm;418nm |
|
6 |
OR; RE
|
GFFP-HLA/B/CBS-05464-ORRE |
573nm;599nm |
548nm;580nm |
|
7 |
OR; OR
|
GFFP-HLA/B/CBS-05464-OROR |
573nm;573nm |
548nm;548nm |
|
8 |
OR; GO
|
GFFP-HLA/B/CBS-05464-ORGO |
573nm;551nm |
548nm;525nm |
|
9 |
OR; GR
|
GFFP-HLA/B/CBS-05464-ORGR |
573nm;515nm |
548nm;491nm |
|
10 |
OR; AQ
|
GFFP-HLA/B/CBS-05464-ORAQ |
573nm;467nm |
548nm;418nm |
|
11 |
GO; RE
|
GFFP-HLA/B/CBS-05464-GORE |
551nm;599nm |
525nm;580nm |
|
12 |
GO; OR
|
GFFP-HLA/B/CBS-05464-GOOR |
551nm;573nm |
525nm;548nm |
|
13 |
GO; GO
|
GFFP-HLA/B/CBS-05464-GOGO |
551nm;551nm |
525nm;525nm |
|
14 |
GO; GR
|
GFFP-HLA/B/CBS-05464-GOGR |
551nm;515nm |
525nm;491nm |
|
15 |
GO; AQ
|
GFFP-HLA/B/CBS-05464-GOAQ |
551nm;467nm |
525nm;418nm |
|
16 |
GR; RE
|
GFFP-HLA/B/CBS-05464-GRRE |
515nm;599nm |
491nm;580nm |
|
17 |
GR; OR
|
GFFP-HLA/B/CBS-05464-GROR |
515nm;573nm |
491nm;548nm |
|
18 |
GR; GO
|
GFFP-HLA/B/CBS-05464-GRGO |
515nm;551nm |
491nm;525nm |
|
19 |
GR; GR
|
GFFP-HLA/B/CBS-05464-GRGR |
515nm;515nm |
491nm;491nm |
|
20 |
GR; AQ
|
GFFP-HLA/B/CBS-05464-GRAQ |
515nm;467nm |
491nm;418nm |
|
21 |
AQ; RE
|
GFFP-HLA/B/CBS-05464-AQRE |
467nm;599nm |
418nm;580nm |
|
22 |
AQ; OR
|
GFFP-HLA/B/CBS-05464-AQOR |
467nm;573nm |
418nm;548nm |
|
23 |
AQ; GO
|
GFFP-HLA/B/CBS-05464-AQGO |
467nm;551nm |
418nm;525nm |
|
24 |
AQ; GR
|
GFFP-HLA/B/CBS-05464-AQGR |
467nm;515nm |
418nm;491nm |
|
25 |
AQ; AQ
|
GFFP-HLA/B/CBS-05464-AQAQ |
467nm;467nm |
418nm;418nm |
|
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